Mixel Capsules Profile

Mixel capsules are a familiar sight in Pakistani infection wards, from ENT clinics at Jinnah Postgraduate Medical Centre in Karachi to general OPDs in Lahore’s Services Hospital, where docs prescribe them for bacterial bugs like those behind UTIs or throat infections. As cefixime, a third-gen cephalosporin, it’s DRAP-approved with specs on dissolution for efficacy, but resistance in local strains pushes sensitivity tests. A strip of 5x200mg capsules costs around PKR 250-300 from High-Q Pharma—grab via Dawaai.pk or Servaid—drawn from routine practices, prescription mandatory to fight overuse.

Ingredients

• Active Ingredient: Cefixime trihydrate 200mg (anhydrous equivalent).
• Excipients: Pregelatinized starch, magnesium stearate, gelatin shell—label for allergens.

Drug Class

Third-Generation Cephalosporin Antibiotic.

How It Functions

Cefixime binds to bacterial PBPs, halting peptidoglycan cross-linking in cell walls for lysis, hitting Gram-negative bugs like E. coli or Klebsiella hard. In Pakistan’s waterborne infection zones, it’s go-to for uncomplicated cases, but docs reserve it for cultures showing sensitivity amid beta-lactamase spread.

Common Applications

Local ID guidelines flag:

• Uncomplicated UTIs or pyelonephritis.
• Otitis media.
• Pharyngitis, tonsillitis.
• Acute bronchitis or exacerbations.
• Uncomplicated gonorrhea (cervical/urethral).

Dosage Form

Capsules swallowed whole, 200-400mg once or twice daily, with or without food.

Potential Side Effects

Typical: Diarrhea, nausea, abdominal pain, dyspepsia, vomiting.

Others: Headache, dizziness.

Serious from reports: Seizures, liver enzyme spikes, jaundice, amylase rise, or severe colitis. Discontinue for watery diarrhea; ER for seizures or yellowing.

Key Warnings and Precautions

DRAP/PMDC notes:

• Renal: Caution in impairment—adjust dose, monitor creatinine.
• Allergies: Cross with penicillins (up to 10%); test history.
• GI: Risk of C. diff overgrowth—avoid in colitis past.
• Pregnancy: Category B—consult if needed.
• Broad-Spectrum: Alters flora; probiotics often co-prescribed.

Elderly or dehydrated get closer renal watches; no alcohol excess.

When It’s Not Suitable (Contraindications)

Pass if:

• Hypersensitive to cefixime or cephalosporins.

Drug Interactions

Flag with doc:

• Anticoagulants (warfarin)—bleed risk up.
• Carbamazepine—levels may rise.
• Probenecid—extends cefixime half-life.

In Case of Overdose

GI upset, seizures possible—hospital for supportive care, hemodialysis if renal hit.

Missed Dose

Take ASAP unless near next; skip, no doubles.

Storage and Disposal

Room temp (15-30°C), dry, away from light/heat/kids. Pharmacy return for leftovers, not flush.

Quick Tips

• With meals if stomach bugs.
• Full course to kill bugs completely.
• Report loose stools or rash early.

Doctor Review

ENT and urology specialists at places like PIC Lahore or Liaquat National Karachi lean on Mixel for community-acquired infections like otitis or cystitis where amoxicillin flops, dosing once-daily for compliance in busy families, but stress cultures given DRAP’s resistance alerts and pair with hydration for desi heat.

Laboratory Screening

Monitor:

• Renal function, LFTs.
• Stool if diarrhea persists.

This pins Mixel’s fight in Pakistan’s bacterial battles—straight reference, doc’s call.

Disclaimer: This is product information only, not a prescription or diagnosis. Consult a qualified Pakistani doctor before using Mixel capsules to ensure it’s safe. Seek immediate care for severe symptoms like seizures, jaundice, or persistent diarrhea.