Description
Glimepiride is an oral antidiabetic medicine used to manage type 2 diabetes mellitus. It works by stimulating the pancreas to release more insulin, which helps lower blood sugar levels. It is usually prescribed when diet, exercise, and metformin alone (or in combination with other antidiabetics) do not provide enough control. Glimepiride does not treat type 1 diabetes or diabetic ketoacidosis. Regular use helps maintain stable blood sugar levels and lowers the risk of complications affecting the heart, kidneys, and nerves.
Uses
Doctors in Pakistan prescribe Glimepiride for:
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Management of type 2 diabetes mellitus (when diet and exercise with metformin are not enough)
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Reducing the risk of diabetes-related complications (heart disease, kidney damage, nerve problems)
How to Use
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Take by mouth with a glass of water.
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Best taken before breakfast or the first main meal of the day.
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Swallow whole — do not crush or chew.
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Take at the same time every day to maintain steady blood sugar levels.
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Always follow the dosage and instructions given by your doctor.
When Not to Use
Do not take Glimepiride if you have:
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Allergy to Glimepiride, sulfonylureas, or related medicines
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Type 1 diabetes or diabetic ketoacidosis
Precautions & Warnings
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Eat meals on time to avoid sudden drops in blood sugar.
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Use with caution if you have liver disease, kidney disease, thyroid problems, or blood disorders.
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Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
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Alcohol may increase the risk of low blood sugar — avoid during treatment.
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Tell your doctor about all other medicines you are taking, especially:
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NSAIDs
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Thyroid medicines
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Blood pressure drugs (beta blockers, ACE inhibitors)
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Possible Side Effects
Some patients may notice:
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Low blood sugar (sweating, dizziness, tremors, hunger)
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Headache
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Nausea or stomach upset
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Weight gain
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Skin rash (rare)
Seek medical help if you experience severe or persistent low blood sugar.
Doctor’s Overview — Dr. Nadia Khan, MBBS, FCPS
Glimepiride is used for type 2 diabetes when diet, exercise, and metformin alone are not enough. It lowers blood sugar effectively but can cause hypoglycemia if meals are skipped. Patients should always take it with food and monitor their blood sugar regularly.
Disclaimer
This overview is for educational purposes only. Glimepiride is a prescription medicine and should be used only under the supervision of a qualified healthcare professional.

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