Perazone

Description Prednisolone 5mg Tablets contain Prednisolone, a corticosteroid that mimics cortisol to reduce inflammation, swelling, and pain. It works by inhibiting inflammatory mediators like prostaglandins and cytokines, suppressing immune responses, and stabilizing cell membranes. These tablets are formulated for adults requiring rapid relief from allergic reactions, autoimmune disorders, or inflammatory conditions, offering potent anti-inflammatory and immunosuppressive effects. Administered orally, they are often used short-term to manage acute symptoms or as part of long-term therapy under strict medical supervision.

Ingredients Prednisolone 5mg.

Drug Class Corticosteroid / Glucocorticoid.

Dosage Form Tablet (Pack size not specified; typically 10 or 30 tablets per strip).

Uses Prednisolone 5mg Tablets are prescribed for:

• Relieving allergic reactions (e.g., anaphylaxis, contact dermatitis, allergic rhinitis).
• Reducing inflammation in conditions like rheumatoid arthritis, lupus, or inflammatory bowel disease.
• Managing swelling, redness, and discomfort in autoimmune or allergic disorders.
• Treating acute exacerbations of asthma or chronic obstructive pulmonary disease (COPD).
• Supporting immunosuppression in organ transplants or autoimmune conditions.
• Controlling flares in skin conditions (e.g., eczema, psoriasis) or joint inflammation.

Doctor’s Review Dr. Ali Raza, a prominent rheumatologist in Islamabad, endorses Prednisolone for its rapid efficacy: “Prednisolone 5mg is a go-to for acute allergic and inflammatory conditions, quickly calming swelling and discomfort. Its low-dose format is ideal for tailored therapy, but I always stress short-term use and tapering to avoid side effects like weight gain or bone loss.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: 5-60mg daily, divided into 1-4 doses, depending on condition severity.
• Allergic/Inflammatory conditions: Start with 10-20mg daily, taper to 5mg maintenance if needed.
• Acute exacerbations: 40-60mg daily for 3-10 days, then taper off.
• Children: 0.5-2mg/kg/day, divided; use only under pediatric guidance.
• Take with food to reduce stomach irritation; do not stop abruptly—taper as directed.

In Case of Overdose Overdose may cause symptoms like increased heart rate, agitation, nausea, or Cushingoid symptoms (e.g., moon face, weight gain). Seek immediate medical attention. Treatment is supportive, including monitoring vitals, managing symptoms, and possibly gastric lavage if recent. Long-term overuse risks adrenal suppression or osteoporosis.

Missed Dose Take as soon as remembered unless close to the next dose. Do not double up to avoid side effects like hypertension or mood changes. Resume your schedule and consult your doctor if misses are frequent to adjust the tapering plan.

How to Use

• Swallow tablet whole with a glass of water, preferably with or after food to minimize GI upset.
• Take at consistent times daily, often morning to mimic cortisol rhythm.
• Do not crush or chew unless specified.
• Follow a tapering schedule if used beyond a few days to prevent adrenal insufficiency.
• Monitor for weight gain, mood swings, or swelling—report to your doctor.

When Not to Use Avoid Prednisolone if:

• Allergic to Prednisolone or other corticosteroids.
• Active systemic fungal infections or untreated bacterial/viral infections.
• Recent live virus vaccination (e.g., measles, varicella).
• Severe liver disease or uncontrolled diabetes.
• Peptic ulcer disease or recent GI perforation.
• Known osteoporosis or severe psychiatric conditions unless benefits outweigh risks.

Side Effects Common:

• Increased appetite, weight gain, insomnia.
• Nausea, stomach pain, bloating.
• Mood changes, irritability, headache.

Uncommon / Severe (Stop and seek medical help):

• Severe allergic reactions (rash, swelling, breathing difficulty).
• Adrenal suppression (fatigue, weakness, low BP).
• High blood sugar, hypertension, osteoporosis.
• GI bleeding, psychosis, or infections (fever, sore throat).

Precautions & Warnings

• Use lowest effective dose for shortest duration to minimize risks.
• Monitor for infection signs, as Prednisolone suppresses immunity.
• Regular bone density, blood sugar, and BP checks needed for long-term use.
• Taper off gradually to avoid adrenal crisis—never stop suddenly.
• Use cautiously in diabetes, heart disease, or history of psychosis.
• Avoid live vaccines during treatment; consult your doctor.
• Elderly patients are more prone to side effects like fractures or hypertension.

Drug Interactions

• NSAIDs (e.g., ibuprofen): Increased GI bleeding risk.
• Antidiabetics: Reduced glucose control—monitor blood sugar.
• Anticoagulants (e.g., warfarin): Altered bleeding risk; check INR.
• CYP3A4 inducers (e.g., rifampicin, phenytoin): Decrease Prednisolone efficacy.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): Increase Prednisolone levels.
• Diuretics (e.g., furosemide): Risk of hypokalemia—monitor electrolytes.
• Vaccines: Reduced response to inactivated vaccines.

Food Interactions

• Take with food or milk to reduce stomach irritation.
• Limit alcohol—heightens GI bleeding risk.
• Avoid grapefruit juice; may increase Prednisolone levels.
• Moderate salt intake to prevent fluid retention or BP spikes.
• Include calcium-rich foods (e.g., dairy, leafy greens) to support bone health.
• Maintain a balanced diet to manage weight gain risk.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and moisture.
• Keep in original packaging, out of reach of children and pets.
• Do not use past expiration date; check package for details.
• Dispose via pharmacy take-back programs; do not flush or trash to prevent misuse.

Quick Tips

• Take with breakfast to align with body’s cortisol cycle.
• Carry a steroid treatment card for emergencies.
• Report fever, mood changes, or bone pain promptly.
• Use calcium/vitamin D supplements if advised to protect bones.
• Avoid abrupt stops—follow your doctor’s tapering plan.
• Monitor BP and glucose at home if long-term use.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.