Plaquin-H

Drug Description:

Plaquin-H contains Hydroxychloroquine Sulphate as the active ingredient, primarily used as an antimalarial and immunomodulatory agent. It is a derivative of chloroquine and is commonly prescribed for treating autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus (SLE), as well as for the prevention and treatment of malaria.

Indications:

Plaquin-H is indicated for the following:

• Rheumatoid arthritis: To manage symptoms and inflammation.

• Systemic lupus erythematosus (SLE): To control disease activity and prevent flare-ups.

• Malaria: For the prevention and treatment of malaria caused by Plasmodium species.

• Immunomodulatory: Used to modulate immune system function in autoimmune conditions.

Dosage Form:

• Tablet: Each tablet contains 200 mg of Hydroxychloroquine Sulphate.

Dosage:

• Rheumatoid Arthritis:

  • Initial dose: 400-600 mg/day (divided doses), followed by a maintenance dose of 200-400 mg/day.

• Systemic Lupus Erythematosus (SLE):

  • Similar dosing as for rheumatoid arthritis (400-600 mg/day initially, then 200-400 mg/day for maintenance).

• Malaria:

  • For prevention: 400 mg weekly, starting 1-2 weeks before travel and continuing for 4 weeks after exposure.

Note: Always follow the prescribed dosage by your healthcare provider as it may vary based on the individual’s condition.

Side Effects:

• Common:

  • Headache, dizziness.

  • Nausea, vomiting.

  • Stomach pain.

  • Loss of appetite, weight loss.

  • Nervousness, irritability.

  • Skin rash, itching.

  • Hair loss.

• Serious:

  • Vision changes (retinal toxicity), heart problems, severe allergic reactions (rash, difficulty breathing, swelling of face or throat).

Precautions & Warnings:

• Muscle Weakness: If you experience muscle weakness, pain, or tenderness, contact your doctor immediately.

• Mental Health Effects: Hydroxychloroquine may cause mood changes, agitation, irritability, or suicidal thoughts. Monitor for any mental health symptoms.

• Eye Exams: Hydroxychloroquine may cause retinal damage with long-term use; regular eye exams are recommended.

• Liver or Kidney Disease: Use with caution in patients with liver or kidney problems. Dose adjustments may be required.

• Pregnancy and Breastfeeding: Use during pregnancy only if clearly needed. Hydroxychloroquine may pass into breast milk.

Drug Interactions:

• Antacids: May reduce absorption of hydroxychloroquine.

• Corticosteroids: May increase the risk of side effects, particularly on the eyes.

• Digoxin: Hydroxychloroquine may enhance the effects of digoxin, increasing the risk of toxicity.

• Other Antimalarial Drugs: Combining with other antimalarial drugs may increase risk of adverse effects.

Contraindications:

• Hypersensitivity: Contraindicated in patients allergic to hydroxychloroquine or similar compounds (e.g., chloroquine).

• Retinal Disease: Contraindicated in patients with pre-existing retinal or visual disturbances.

• Porphyria: Contraindicated in patients with porphyria.

Pregnancy Category:

Category C – Hydroxychloroquine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Storage:

• Store at room temperature (20°C to 25°C / 68°F to 77°F).

• Keep in a dry place, away from light.

How Supplied:

• Plaquin-H Tablets: Each tablet contains 200 mg of Hydroxychloroquine Sulphate.

• Available in bottles or blister packs.

Doctor’s Overview — Dr. Hina Qureshi, MBBS, FCPS

Plaquin-H effectively manages autoimmune conditions like rheumatoid arthritis and lupus. However, long-term use requires monitoring for side effects, especially vision and mood changes. Regular check-ups are recommended to ensure safe use.

Medical Disclaimer:

This information is provided for educational purposes only and is not a prescription. Always consult a healthcare provider for proper diagnosis, dosage, and treatment.