Platlo

Platlo Tablets contain Clopidogrel, an antiplatelet agent used to prevent blood clots in patients at risk of stroke, myocardial infarction, or peripheral arterial disease. It inhibits platelet aggregation by selectively blocking the P2Y12 ADP receptor, thereby reducing the formation of thrombi and improving vascular blood flow. Platlo plays a key role in secondary prevention of atherothrombotic events, especially in patients intolerant to or requiring dual therapy with aspirin.

Primary Uses

• Prevention of stroke and myocardial infarction.

• Secondary prevention of atherothrombotic events in coronary or peripheral artery disease.

• Prevention of thromboembolic events in atrial fibrillation (with aspirin when warfarin unsuitable).

Indications

Indicated for adult patients with:

• Recent myocardial infarction (within 35 days).

• Ischemic stroke (within 6 months).

• Established peripheral arterial disease.

• Atrial fibrillation with vascular risk factors, where Vitamin K antagonists are not appropriate.

How It Works

Clopidogrel is a prodrug that requires CYP450 enzyme metabolism to form its active metabolite. This metabolite irreversibly blocks ADP binding to platelet P2Y12 receptors, preventing activation of the GPIIb/IIIa complex and platelet aggregation. The inhibition lasts for the lifespan of platelets (7–10 days), ensuring prolonged antithrombotic protection.

Dosage

Adults: 75 mg once daily, with or without food, as directed by a physician.
Do not discontinue abruptly without consulting your doctor, especially after a stroke or heart procedure.

Side Effects

Common side effects include:

• Gastrointestinal: Abdominal pain, diarrhea, nausea, gastritis, constipation, GI bleeding or ulceration.

• Neurological: Headache, dizziness, drowsiness, paresthesia.

• Hematologic: Neutropenia, prolonged bleeding, bruising.

• Cardiac: Palpitations, hypotension (rare).

Seek immediate care for prolonged or unexplained bleeding.

Drug Interactions

• Warfarin, Heparin, ASA, Glycoprotein IIb/IIIa inhibitors: Increased bleeding risk.

• NSAIDs, SSRIs: Enhanced antiplatelet effect.

• Omeprazole, Esomeprazole, Fluoxetine, Fluconazole, Carbamazepine, Efavirenz: Reduce Clopidogrel activation (avoid or use alternatives).

Warnings & Precautions

• Bleeding Risk: Monitor for visible or hidden bleeding, especially during early therapy or post-surgery.

• Acquired Hemophilia: If unexplained prolonged aPTT occurs, stop Clopidogrel and investigate.

• Recent Stroke: Avoid use within the first 7 days of acute ischemic stroke.

• Hepatic Impairment: Use cautiously in moderate impairment; avoid in severe cases.

• Pre-Surgery: Discontinue 5–7 days before planned procedures.

Contraindications

Do not use in:

• Hypersensitivity to Clopidogrel or formulation ingredients

• Active bleeding (peptic ulcer, intracranial hemorrhage)

• Severe hepatic disease

Doctor Review

Dr. Hammad Raza, MBBS, FCPS (Cardiology) – Consultant Interventional Cardiologist:
“Clopidogrel remains a cornerstone therapy in secondary prevention of ischemic stroke and coronary events, particularly in dual antiplatelet regimens post-PCI or stenting. CYP2C19 metabolism plays a critical role in response variability—patients with reduced-function alleles may require alternative agents like Ticagrelor. Clinical trials such as CAPRIE have demonstrated a relative risk reduction of 8.7% in ischemic events compared with aspirin monotherapy. Regular review for bleeding, GI tolerance, and drug interactions—especially with PPIs—is vital for optimized safety.”

Pregnancy & Lactation

Use only if clearly needed and prescribed by a physician. Safety data in pregnancy and breastfeeding are limited.

Storage

Store at room temperature, away from sunlight and moisture. Keep out of reach of children.

Disclaimer

This information is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified physician before starting, changing, or stopping any medication. CureCart Direct ensures information accuracy but cannot cover all possible interactions or precautions.