Pyloclar

Pyloclar tablets are a regular in Pakistani respiratory and ENT clinics, from Civil Hospital Karachi to Lady Reading in Peshawar, where doctors use them for bacterial pneumonia or sinusitis when cultures show sensitive bugs. As clarithromycin, a macrolide, it’s DRAP-approved but faces rising resistance in H. pylori and respiratory pathogens per local studies, often in quadruple therapy for ulcers. A strip of 10x500mg from High-Q Pharma costs PKR 550-930—check Dawaai.pk or Healthwire for stock—pulled from OPD protocols, prescription essential to stem misuse.

Ingredients

• Active Ingredient: Clarithromycin 500mg (as clarithromycin base).
• Excipients: Croscarmellose sodium, magnesium stearate, hypromellose—label for allergens.

Drug Class

Macrolide Antibiotic.

How It Functions

Clarithromycin latches onto the 50S ribosomal subunit of bacteria, halting protein synthesis and curbing growth. In Pakistan’s dusty urban air, it tackles atypicals like Mycoplasma in bronchitis, but docs test for MIC amid 17-36% resistance rates in gastric bugs.

Common Applications

Local pulmo and ID guidelines target:

• Lower RTI like bronchitis or pneumonia.
• Upper RTI including pharyngitis, tonsillitis, sinusitis.
• Skin/soft tissue infections (folliculitis, cellulitis).
• Disseminated Mycobacterium avium complex or other nontuberculous mycobacteria.
• H. pylori eradication in combos.

Dosage Form

Tablets taken orally, 250-500mg twice daily with food.

Potential Side Effects

Common: Diarrhea, nausea, odd taste, dyspepsia, abdominal pain, headache.

Others: Glossitis, vomiting, dizziness.

Serious from reports: Allergic reactions (urticaria to SJS/TEN), blood count drops (thrombocytopenia, neutropenia), QT prolongation (arrhythmias), liver issues (hepatitis, jaundice), rare hearing loss or tooth staining. ER for rash, palpitations, or dark urine.

Key Warnings and Precautions

DRAP/PMDC stresses:

• Liver: Monitor enzymes; discontinue on jaundice or tender abdomen—reversible but fatal cases in sick patients.
• Renal: Caution in severe insufficiency—adjust dose.
• Pregnancy: Category C—first trimester weigh risks; lactation okay.
• Superinfections: Long use risks fungal or resistant bugs.
• Heart: QT risk higher with certain meds; ECG if history.

Shortest course; elderly or Asian get lower starts per resistance data.

When It’s Not Suitable (Contraindications)

Avoid if:

• Hypersensitive to macrolides or excipients.
• With astemizole, cisapride, pimozide, terfenadine (QT risk).
• Ergot alkaloids or oral midazolam.

Drug Interactions

Alert doc:

• Statins (lovastatin)—rhabdo risk.
• Cisapride/pimozide—arrhythmias.
• Midazolam, ergotamine—toxicity.
• Warfarin—bleed up.

In Case of Overdose

GI upset, liver strain—hospital for supportive; no antidote.

Missed Dose

Take soon unless near next; skip, no doubles.

Storage and Disposal

Room temp (15-30°C), dry, light/heat-free, kid-safe. Pharmacy return unused, not flush.

Quick Tips

• With meals to ease stomach.
• Full course despite taste changes.
• Report yellowing or heart flutters fast.

Doctor Review

Pulmonologists at PIC or ENT at KMC Peshawar prescribe Pyloclar for community pneumonia in clarithromycin-sensitive cases, but swap to levofloxacin amid 30%+ resistance in H. pylori per Rawalpindi studies, often in bismuth quad with PPI for ulcers common in desi diets.

Laboratory Screening

Track:

• LFTs, renal function, CBC.
• ECG if cardiac risks.
• Cultures for sensitivity.

This frames Pyloclar’s bacterial battle in Pakistan—awareness aid, doc decides.

Disclaimer: This is product information only, not a prescription or diagnosis. Consult a qualified Pakistani doctor before using Pyloclar tablets to ensure it’s safe. Seek immediate care for severe symptoms like rash, jaundice, or irregular heartbeat.