This tablet combines L-Methylfolate, Methylcobalamin, and N-acetylcysteine to support nerve health, boost antioxidant defenses, and aid in processes like DNA methylation and neurotransmitter production. L-Methylfolate, the active form of folate, helps with brain function and cell repair. Methylcobalamin, a form of vitamin B12, supports nerve function and keeps homocysteine levels in check. N-acetylcysteine (NAC) fuels glutathione production, a key antioxidant that fights oxidative stress and supports liver health. Together, they offer a multi-angle approach to improving cognitive health, reducing stress on cells, and supporting overall wellness, particularly for neurological or mood-related concerns.
Expert Review
Dr. David Perlmutter, a neurologist and author known for his work on brain health, highlights the value of these ingredients in supporting neurological function. He notes that L-Methylfolate and Methylcobalamin play critical roles in methylation pathways, which are essential for neurotransmitter balance and cognitive health, while NAC’s antioxidant properties help protect brain cells from oxidative damage. Dr. Perlmutter emphasizes that this combination can be particularly useful for supporting mental clarity and nerve health but advises careful monitoring for individual tolerances, especially in those with pre-existing conditions.
Primary Uses
This tablet is used to:
- Address vitamin B12 and folate deficiencies, supporting nerve and cognitive function.
- Promote liver health and detoxification.
- Reduce oxidative stress and boost antioxidant defenses.
- Support red blood cell production and cardiovascular health.
- Enhance mental well-being and promote healthy skin and hair.
Indications
Prescribed for folate or B12 deficiencies, neurological support, liver detoxification, and conditions involving oxidative stress or poor homocysteine metabolism.
Side Effects
Some may experience nausea, diarrhea, constipation, abdominal pain, headaches, dizziness, skin rashes, itching, insomnia, or mood changes like anxiety. Consult your doctor if these occur.
Warnings
- Pregnancy: Consult your doctor before use.
- Lactation: Check with your doctor, as it may not be safe while breastfeeding.
- Driving: Avoid driving if you feel dizzy or lightheaded after taking this tablet.
- Alcohol: Limit alcohol to avoid reducing the tablet’s effectiveness or depleting vitamins.
Precautions
- Use cautiously if you have allergies, neurological disorders, or asthma, as NAC may cause bronchospasm.
- Monitor for interactions with medications like anticonvulsants or methotrexate.
- Avoid exceeding the recommended dose to prevent nerve or skin issues.
- Discuss with your doctor if you have kidney, liver, or psychiatric conditions.
Contraindications
Avoid if:
- Allergic to L-Methylfolate, Methylcobalamin, N-acetylcysteine, or tablet excipients.
- You have pernicious anemia, uncontrolled hypertension, active liver disease, epilepsy, renal impairment, active cancer, or a history of stroke or cardiovascular disease.
How to Use
Swallow the tablet whole with water, ideally in the morning on an empty stomach, 30 minutes before a meal, or as directed by your doctor. Do not crush or chew. Take consistently at the same time daily and stay hydrated.
In Case of Overdose
Overdose may cause nausea, vomiting, diarrhea, or abdominal pain. Seek medical help immediately for guidance and supportive care.
Missed Dose
Take a missed dose as soon as you remember, unless it’s near your next dose. Skip the missed dose if it’s almost time for the next one, and never double up to avoid side effects. Use reminders or a pill organizer to stay on track.
Drug Interactions
- May interact with betaine, chemotherapy drugs, chloramphenicol, nitroglycerin, or activated charcoal, affecting their effectiveness.
- Consult your doctor before combining with alcohol, as it may impact metabolism of L-Methylfolate and NAC.
Food Interactions
- Limit high-protein foods, grapefruit, dairy, or nitrate-rich foods (e.g., processed meats), as they may affect absorption or metabolism.
- Avoid excessive vitamin C intake during treatment.
- Maintain a balanced diet with B vitamins to support the tablet’s effects.
Storage/Disposal
Store in a cool, dry place, away from sunlight, moisture, and heat, in the original container with a tight seal. Check expiration dates and dispose of expired or unused tablets responsibly through a pharmacist, not by flushing or pouring down the drain. Keep out of reach of children and pets.
Quick Tips
- Follow your doctor’s dosage and timing instructions.
- Take on an empty stomach unless advised otherwise.
- Stay hydrated and maintain a consistent schedule.
- Don’t share your medication, even if others have similar symptoms.
Disclaimer
This information is for general guidance only. Consult a doctor for personalized advice on side effects, precautions, or interactions, as individual needs vary.

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