S-Gliptin Plus

Description S-Gliptin Plus Tablets 50/850mg combine Sitagliptin (50mg) and Metformin HCl (850mg), two complementary antidiabetic agents for managing type 2 diabetes mellitus. Sitagliptin, a DPP-4 inhibitor, boosts insulin release and reduces glucagon post-meals, stabilizing blood sugar. Metformin, a biguanide, lowers liver glucose production, enhances insulin sensitivity, and decreases intestinal glucose absorption. Manufactured by Barrett Hodgson Pakistan (Pvt) Ltd, this tablet offers effective glycemic control with minimal weight gain risk, ideal for adults needing combination therapy.

Ingredients Sitagliptin 50mg, Metformin HCl 850mg.

Drug Class Antidiabetic / DPP-4 Inhibitor and Biguanide Combination.

Dosage Form Tablet (Pack size not specified; typically 14 or 28 tablets per strip).

Uses S-Gliptin Plus Tablets are prescribed for:

• Controlling elevated blood sugar in type 2 diabetes mellitus.
• Dual therapy when Metformin or Sitagliptin alone is inadequate.
• Reducing risks of diabetes complications (e.g., cardiovascular issues, neuropathy, kidney or eye damage).
• Combination with other antidiabetics (e.g., insulin, sulfonylureas) for enhanced control.
• Supporting glycemic management without significant weight gain.

Doctor’s Review Endocrinologists value S-Gliptin Plus for its synergistic action and patient-friendly profile. As one specialist notes: “S-Gliptin Plus is a go-to for type 2 diabetes when single-drug therapy falls short. Its dual mechanism tackles glucose from multiple angles, and the low hypoglycemia risk makes it practical for daily use, provided kidney function is monitored.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: One tablet (50mg Sitagliptin/850mg Metformin) twice daily with meals.
• Adjustments: May titrate to 100mg Sitagliptin/2000mg Metformin daily, based on glucose levels and kidney function.
• Renal impairment: Reduce dose if GFR 30-45 mL/min; avoid if GFR <30 mL/min.
• Take consistently to minimize GI upset; do not split or chew tablets.

In Case of Overdose Overdose may cause lactic acidosis (Metformin-related) or severe hypoglycemia, with symptoms like muscle pain, breathing difficulty, dizziness, or confusion. Seek emergency medical help immediately. Treatment includes supportive care, hemodialysis for Metformin removal, or glucose for hypoglycemia. Monitor for pancreatitis or heart rhythm issues.

Missed Dose Take as soon as remembered unless close to the next dose. Do not double up to avoid risks like nausea or low blood sugar. Resume your regular schedule and consult your doctor if doses are frequently missed.

How to Use

• Swallow tablet whole with water, ideally with meals to reduce stomach upset.
• Take at consistent times (e.g., morning and evening) for steady levels.
• Follow a diabetes-friendly diet and exercise plan as prescribed.
• Monitor blood sugar regularly with a glucometer.
• Watch for signs of low blood sugar (sweating, shakiness) and keep glucose tabs handy.

When Not to Use Avoid S-Gliptin Plus if:

• Severe renal impairment (GFR <30 mL/min).
• Diabetic ketoacidosis or type 1 diabetes.
• Severe liver disease or acute heart failure.
• Hypersensitivity to Sitagliptin, Metformin, or any excipients.
• Recent heart attack, shock, or acute alcohol intoxication.

Side Effects Common:

• Nausea, vomiting, diarrhea, abdominal pain, gas.
• Headache, sore throat, nasal congestion.
• Metallic taste or mild weight loss.

Uncommon / Severe (Stop and seek medical help):

• Lactic acidosis (muscle pain, weakness, breathing issues, irregular heartbeat).
• Pancreatitis (severe abdominal pain, nausea, vomiting).
• Hypoglycemia (shakiness, sweating, confusion).
• Allergic reactions (rash, itching, swelling).

Precautions & Warnings

• Check kidney function (GFR) before and during use—stop if renal decline occurs.
• Avoid in liver disease or severe heart failure due to lactic acidosis risk.
• Monitor for pancreatitis signs, especially with prior history.
• Hypoglycemia risk rises with insulin or sulfonylureas—adjust doses.
• Stay hydrated; report dehydration or unusual symptoms promptly.

Drug Interactions

• Increase Metformin levels: Cimetidine, dolutegravir, ranolazine.
• Increase hypoglycemia risk: Insulin, sulfonylureas, NSAIDs.
• Reduce efficacy: Diuretics, corticosteroids, phenytoin.
• Contrast dyes: Stop temporarily before iodinated contrast procedures.

Food Interactions

• Take with meals to lessen GI side effects.
• Limit alcohol—heightens lactic acidosis risk.
• Avoid high-carb meals to support glucose control.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and heat.
• Keep in original packaging, out of reach of children.
• Dispose via pharmacy returns; do not flush.

Quick Tips

• Test blood sugar daily, especially during dose changes.
• Carry a diabetes ID or alert card.
• Eat fiber-rich foods to ease digestive side effects.
• Report persistent abdominal pain or weakness immediately.
• Schedule regular HbA1c checks to track progress.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.