Seloxx

Description

Seloxx (Celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the COX-2 inhibitors class. It provides anti-inflammatory, analgesic, and antipyretic effects by selectively inhibiting the enzyme cyclooxygenase-2 (COX-2), which reduces prostaglandin synthesis responsible for pain and inflammation. Unlike traditional NSAIDs, celecoxib generally spares COX-1, lowering the risk of stomach ulcers while still offering strong relief from pain and inflammation.

Brand

• Seloxx – Schazoo Pharmaceuticals

Generic Name

• Celecoxib

Strength & Form

• 100mg Capsules

• 1 Box = 1 Strip (10 Capsules)

Prescription

• Prescription Required

Used For

• Pain & Inflammation

Indications

Seloxx (Celecoxib) is indicated for:

1. Relief of signs and symptoms of osteoarthritis

2. Relief of signs and symptoms of rheumatoid arthritis in adults

3. Symptomatic relief in ankylosing spondylitis

4. Relief of signs and symptoms of juvenile rheumatoid arthritis (JRA) in patients 2 years and older

5. Management of acute pain in adults, including post-operative pain

How It Works

• Celecoxib selectively blocks COX-2 enzymes, reducing prostaglandin production that causes inflammation, pain, and fever.

• At therapeutic concentrations, it generally does not inhibit COX-1, which helps protect the stomach lining.

Dosage

• Dosage is individualized depending on the condition, age, and severity.

• Always follow the prescribing physician’s directions.

Side Effects

Common:

• Abdominal pain, diarrhea, dyspepsia, flatulence, nausea

• Dizziness, headache

• Sinusitis, pharyngitis, upper respiratory tract infection

• Back pain, insomnia, skin rash

Less Common:

• Constipation, vomiting, gastritis, reflux, stomatitis

• Hypertension, angina, palpitations

• Bronchospasm, cough, pneumonia

• Depression, anxiety, somnolence, fatigue

Rare/Serious:

• Heart failure, myocardial infarction, pulmonary embolism

• Gastrointestinal bleeding, ulcers, colitis with bleeding

• Hepatitis, pancreatitis, renal failure, interstitial nephritis

• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)

• Blood disorders (thrombocytopenia, aplastic anemia, leukopenia)

• Anaphylactic reactions, angioedema

Drug Interactions

Celecoxib may interact with:

• ACE inhibitors & angiotensin II antagonists (reduce effectiveness, increase renal risk)

• Furosemide & thiazides (reduced diuretic effect)

• Aspirin & other NSAIDs (increased risk of GI bleeding)

• Fluconazole (increases celecoxib levels)

• Lithium (increased serum lithium levels)

• Warfarin (increased risk of bleeding)

• Glucocorticoids (higher risk of GI complications)

• Antacids (may alter absorption)

Contraindications

Do not use Seloxx if you have:

• Allergy to celecoxib, sulfonamides, aspirin, or other NSAIDs

• History of asthma, urticaria, or severe allergic reactions to NSAIDs

• Renal impairment (creatinine clearance <30 mL/min)

• Severe hepatic impairment (Child-Pugh Class C)

• Active peptic ulcer or gastrointestinal bleeding

• History of myocardial infarction, stroke, ischemic heart disease, heart failure, or peripheral artery disease

• Use around coronary artery bypass graft (CABG) surgery

Warnings & Precautions

• Fluid retention & edema may occur; use cautiously in heart failure and hypertension.

• May cause new or worsening hypertension, increasing cardiovascular risk.

• Liver dysfunction: monitor patients with abnormal liver tests; discontinue if severe symptoms develop.

• Not a substitute for corticosteroids—avoid abrupt steroid withdrawal.

Pregnancy & Lactation

• Pregnancy: Use only if clearly needed; consult physician.

• Lactation: Consult healthcare provider before use.

Storage

• Store at room temperature (15°C–30°C)

• Protect from direct light, heat, and moisture

• Keep out of reach of children

Doctor’s Review

Dr. Imran Qureshi – Consultant Rheumatologist
“Celecoxib is a COX-2 selective NSAID that helps manage pain and inflammation effectively, particularly in arthritis and acute pain conditions. It has a lower risk of gastric irritation compared to traditional NSAIDs, but patients with cardiovascular, kidney, or liver conditions must use it cautiously under medical supervision.”

Disclaimer

This information is provided for educational purposes only. It is not a substitute for professional medical advice. Always consult your doctor or pharmacist for personalized recommendations before starting or adjusting any medication.