Stomacol

Stomacol tablets pop up in Pakistani gastro clinics, from Aga Khan in Karachi to Mayo Hospital Lahore, where doctors hand them out for nausea and vomiting tied to indigestion or meds. As domperidone maleate, it’s a dopamine blocker that eases gut motility, but PMDC and DRAP flag cardiac risks like QT prolongation, especially over 30mg daily or in over-60s—often limited to short-term use amid self-medication concerns here. A strip of 10x10mg runs PKR 50-100, generics from Rasco Pharma—check Dawaai.pk or Servaid—local protocol facts, prescription required despite OTC slips.

Ingredients

• Active Ingredient: Domperidone maleate 10mg (equivalent to domperidone 9.17mg).
• Excipients: Starch, lactose, magnesium stearate—label for full; avoid if lactose issues.

Drug Class

Dopamine D2 Receptor Antagonist (Prokinetic Anti-Emetic).

How It Functions

Domperidone mixes gut speed-up by blocking peripheral dopamine receptors with central action on the chemoreceptor trigger zone outside the blood-brain barrier, cutting nausea signals. In Pakistan’s spice-heavy diets, it helps post-meal bloating, but docs pair ECG checks for heart-safe dosing.

Common Applications

Per local gastro guidelines:

• Nausea and vomiting from gastritis, drugs, or motion.
• Gastroparesis or reflux symptoms.
• Dyspepsia with upper abdominal discomfort.

Dosage Form

Tablets taken orally, 10mg up to 3-4 times daily before meals, max 30mg/day short-term.

Potential Side Effects

Common: Headache (5.6%), diarrhea (5.2%), rash (2.8%), breast tenderness (4.4%).

Others: Drowsiness (2.5%), anxiety (1.6%), irregular periods (2.0%).

Serious from reports: Galactorrhea (3.3%), gynecomastia (5.3%), akathisia (1%), or cardiac arrhythmia signs (palpitations, fainting). ER for chest pain or sudden dizziness.

Key Warnings and Precautions

DRAP/PMDC stresses:

• Heart: QT prolongation risk—avoid if CHF, electrolytes off, or >60 without ECG; stop if arrhythmia symptoms.
• Liver: Moderate/severe impairment contraindicates; mild, dose low.
• Pregnancy: Consult—limited data, Category C.
• Breastfeeding: Enters milk, may affect baby; avoid.
• Elderly: Higher cardiac hit—physician consult mandatory.

No grapefruit; monitor prolactin for breast issues. Shortest duration to curb risks.

When It’s Not Suitable (Contraindications)

Skip if:

• Moderate/severe liver disease.
• Known QT prolongation, electrolyte imbalance, or cardiac issues like CHF.
• Allergy to domperidone.

Drug Interactions

Alert doc:

• CYP3A4 inhibitors (indinavir, ketoconazole)—levels spike, cardiac risk up.
• QT drugs: Antiarrhythmics (amiodarone, quinidine), antipsychotics (haloperidol), antibiotics (erythromycin).
• Antidepressants (citalopram), antimalarials (halofantrinol)—arrhythmia potential.

In Case of Overdose

Extrapyramidal symptoms, drowsiness—hospital for ECG, supportive care; activated charcoal if recent.

Missed Dose

Take when remembered unless near next; skip, no double.

Storage and Disposal

Room temp (15-30°C), dry, away from light/heat/kids. Pharmacy disposal for unused.

Quick Tips

• Before meals for best gut effect.
• With water, no crushing.
• Report heart flutters or breast changes fast.
• Limit to 1 week unless doc says.

Doctor Review

Gastroenterologists at PIMS Islamabad or Liaquat National Karachi prescribe Stomacol for acute nausea where ondansetron’s too strong, but cap at 30mg/day with baseline ECGs given local sudden death links—favor alternatives in cardiac patients, pushing awareness on OTC misuse.

Laboratory Screening

If ongoing:

• ECG for QT.
• LFTs, electrolytes.
• Prolactin if breast symptoms.

This spots Stomacol’s anti-nausea role in Pakistan—context for informed talk, doc decides.

Disclaimer: This is product information only, not a prescription or diagnosis. Consult a qualified Pakistani doctor before using Stomacol tablets to ensure it’s safe. Seek immediate care for severe symptoms like palpitations, fainting, or swelling.