Wizy 400 mg Capsules – 5 Capsules

Brand: Zephyr Pharmatec (Pvt.) Ltd.
Generic Name: Cefixime 400 mg
Drug Class: Cephalosporin Antibiotic
Dosage Form: Capsule

Cefixime is a third-generation cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, binding to penicillin-binding proteins (PBPs), which leads to a weakened bacterial cell wall and ultimately bacterial death. This mechanism is effective against a broad spectrum of susceptible bacteria, including those causing respiratory, urinary, and skin infections.

Primary Uses / Indications

Cefixime 400 mg capsules are prescribed for:

• Respiratory tract infections: pneumonia, bronchitis, pharyngitis, tonsillitis

• Urinary tract infections: cystitis, pyelonephritis

• Skin and soft tissue infections

• Bone and joint infections

• Gonorrhea (uncomplicated cases)

• Surgical prophylaxis to prevent infections

• Severe bacterial infections requiring high-dose antibiotics

Dosage

Adult Dose:

• 400 mg once daily or divided every 12–24 hours (based on infection type)

Pediatric Dose:

• 6 months – 12 years / ≤45 kg: 8 mg/kg/day, either as single or divided doses

• >12 years / >45 kg: 400 mg once daily

Note: Always follow the prescription of a healthcare professional.

How to Use

• Swallow the capsule whole with a full glass of water.

• Can be taken with or without food.

• Take at the same time every day to maintain consistent blood levels.

• Complete the full prescribed course even if symptoms improve.

Missed Dose

• Take as soon as remembered.

• If near the next dose, skip the missed dose.

• Do not double the dose to compensate.

• For multiple missed doses, consult your doctor.

Overdose

• Symptoms may include nausea, vomiting, diarrhea, abdominal pain.

• Seek medical attention immediately.

• Treatment involves supportive care and monitoring of vital signs.

When Not to Use / Contraindications

• Allergy to cefixime or other cephalosporins

• Severe gastrointestinal diseases (e.g., colitis)

• Severe kidney impairment or failure

• Infants below 6 months

• History of severe allergic reactions

Side Effects

Common side effects may include:

• Diarrhea, nausea, vomiting, abdominal pain

• Skin rash, itching

• Headache, dizziness

• Vaginal yeast infection, fatigue

Precautions & Warnings

• Adjust dose in kidney impairment

• May decrease effectiveness of hormonal contraception – use alternative methods

• Avoid alcohol

• Elderly patients may require monitoring

• Use cautiously during pregnancy and breastfeeding

• Risk of Clostridium difficile-associated diarrhea

Drug Interactions

• Probenecid: increases cefixime levels

• Nephrotoxic drugs: increase kidney toxicity risk

• Oral contraceptives: reduced effectiveness

• Antacids, iron supplements, dairy: may reduce absorption

• Anticoagulants (warfarin): increased bleeding risk

• May affect metabolism of certain liver-metabolized drugs

• Concurrent aminoglycosides may increase kidney/hearing risk

Food Interactions

• Avoid alcohol

• Grapefruit may increase blood levels of cefixime

• Take 2 hours apart from dairy or iron-rich foods

• High-fat meals may delay absorption

• Probiotics may reduce effectiveness

Storage / Disposal

• Store in a cool, dry place at room temperature

• Protect from sunlight and moisture

• Keep out of reach of children

• Dispose responsibly, do not flush

Laboratory Screening / Monitoring

• Blood Culture Test: To confirm bacterial infections

• TyphiDot (IgM) Test: To confirm typhoid fever

• Renal Function Test: Monitor kidney function during treatment

• CBC Blood Test: Monitor for anemia risk

Quick Tips

• Take capsule whole, do not crush or chew

• Maintain consistent dosing

• Complete full course

• Inform doctor about allergies or medical conditions

Doctor’s Review

“Wizy 400 mg (Cefixime) is a broad-spectrum cephalosporin antibiotic, effective against respiratory, urinary, and skin infections. It is safe when used under medical supervision, but caution is advised in patients with kidney disease or allergies to beta-lactam antibiotics. Completing the full course is crucial to prevent antibiotic resistance.”

Disclaimer

The information provided is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing medication. Individual responses, allergies, and contraindications may vary. Follow your healthcare provider’s instructions carefully.