Zeldox

Zeldox (Ziprasidone) is an atypical antipsychotic used in the management of schizophrenia, bipolar disorder, and related psychotic conditions. It helps stabilize mood, reduce hallucinations, and control disorganized thinking by balancing dopamine and serotonin activity in the brain.

Key Benefits

• Effective control of acute and chronic schizophrenia symptoms.

• Helps stabilize mood in bipolar mania.

• Low risk of weight gain compared to older antipsychotics.

• Improves clarity of thought, concentration, and social functioning.

• Can reduce agitation and restlessness with regular use.

How It Works

Ziprasidone acts by modulating dopamine (D2) and serotonin (5-HT2A) receptors in the brain. This dual receptor action corrects chemical imbalances responsible for delusions, mood swings, and hallucinations, resulting in improved emotional stability and cognitive function.

How to Use

• Dose: As prescribed by a psychiatrist; typically once or twice daily with food for better absorption.

• Consistency: Take at the same time daily. Do not skip doses.

• Duration: Long-term maintenance under medical supervision.

• Missed Dose: Take as soon as remembered unless it’s near the next dose. Do not double.

Doctor Review

Dr. Adeel Khan, MBBS, FCPS – Consultant Psychiatrist:
“Zeldox offers balanced dopamine and serotonin antagonism, making it a reliable choice for both acute psychosis and maintenance therapy in schizophrenia. Its lower metabolic side effect profile compared to olanzapine or risperidone improves compliance, especially in long-term patients. ECG monitoring is recommended due to QT prolongation risk, particularly in cardiac patients or those on interacting medications.”

Primary Uses

• Schizophrenia and schizoaffective disorders.

• Acute manic or mixed episodes in bipolar I disorder.

• Maintenance therapy after stabilization.

Side Effects

Common: Drowsiness, dizziness, nausea, mild tremors, headache, restlessness (akathisia)
Less Common: Muscle stiffness, vision changes, indigestion, constipation, anxiety
Serious (rare): Irregular heartbeat, fainting, high fever, muscle rigidity, confusion (possible neuroleptic malignant syndrome)

Warnings and Precautions

Pregnancy: Use only if clearly needed; consult doctor before starting.
Lactation: Not recommended during breastfeeding.
Cardiac: Avoid in QT prolongation, recent MI, or heart failure.
Metabolic: Monitor blood sugar and lipid levels during long-term therapy.
CNS Depression: Avoid alcohol or sedatives; may increase drowsiness or dizziness.
Other: Caution in seizure disorders and patients with electrolyte imbalance.

Contraindications

• Known hypersensitivity to Ziprasidone.

• History of QT prolongation or severe arrhythmia.

• Recent myocardial infarction or uncontrolled heart failure.

• Concurrent use with QT-prolonging drugs (Class IA/III antiarrhythmics).

Drug Interactions

• Antiarrythmics: Amiodarone, quinidine – increase QT risk.

• CNS depressants: Alcohol, benzodiazepines – enhanced sedation.

• Antihypertensives: Additive hypotension possible.

• Antidepressants: SSRIs may enhance serotonergic effects.

Expert Tips from CureCart Direct

• Take with food to ensure full absorption.

• Avoid alcohol and unnecessary sedatives.

• Report palpitations or fainting immediately.

• Do not stop abruptly—may cause withdrawal or symptom relapse.

• Attend regular ECG and blood tests for safety monitoring.

Storage

Store below 25°C, away from heat and moisture. Keep out of children’s reach.

Disclaimer: This information is for educational purposes only and not a medical prescription. Use Zeldox strictly under the supervision of a qualified psychiatrist. CureCart Direct ensures accuracy but does not replace clinical judgment.