Zumin

Description

Esomeprazole 40mg Capsule contains Esomeprazole, a proton pump inhibitor (PPI) that targets and inhibits proton pumps in the stomach’s parietal cells. By blocking potassium-hydrogen exchange, it reduces gastric acid secretion at the final stage of acid production. This makes it highly effective in managing gastric acidity and providing relief from conditions caused by excess stomach acid.

Ingredients

• Esomeprazole 40mg

Drug Class

• Proton Pump Inhibitor (PPI)

Dosage Form

• Capsule

Uses

Esomeprazole 40mg Capsule is used for:

• Treating gastroesophageal reflux disease (GERD).

• Relieving symptoms of acid reflux and heartburn.

• Healing and preventing stomach and duodenal ulcers.

• Treating conditions with excessive stomach acid production.

• Managing acid reflux symptoms in patients with erosive esophagitis.

• Long-term treatment of Zollinger-Ellison syndrome.

• Improving acid-related symptoms and promoting healing.

Dosage

• Adults:

  • Gastric ulcer: 20–40mg once daily for up to 6 months.

  • Duodenal ulcer with H. pylori: 40mg once daily for 10 days (may combine with amoxicillin and clarithromycin).

  • Erosive esophagitis: 20–40mg once daily for 4–8 weeks.

  • GERD: 20mg once daily for 4 weeks.

  • Zollinger-Ellison syndrome: 40mg twice daily.

• Children:

  • 12–17 years: 20–40mg once daily for 4–8 weeks.

  • 1–11 years (≥20kg): 10–20mg once daily for 8 weeks.

  • 1–11 years (<20kg): 10mg once daily for 8 weeks.

  • 1 month–<1 year (>7.5–12kg): 10mg once daily for 6 weeks.

  • 1 month–<1 year (>5–7.5kg): 5mg once daily for 6 weeks.

  • 1 month–<1 year (3–5kg): 2.5mg once daily for 6 weeks.

Always follow your doctor’s prescription.

How to Use

• Swallow the capsule whole with a full glass of water.

• Take preferably in the morning before a meal.

• Do not crush, chew, or open the capsule.

• Follow the full course even if symptoms improve.

Missed Dose

• Take the missed dose as soon as remembered.

• If it is almost time for the next dose, skip the missed one.

• Do not double the dose.

Overdose

Symptoms may include dizziness, blurred vision, rapid heartbeat, nausea, and gastrointestinal distress. Seek immediate medical attention if overdose is suspected.

When Not to Use

• Allergy to Esomeprazole or other PPIs.

• Severe liver impairment.

• Low magnesium or risk of hypomagnesemia.

• History of hypersensitivity to similar medications.

• Long-term use without medical supervision.

Side Effects

• Headache.

• Diarrhea.

• Nausea and vomiting.

• Abdominal pain.

• Dizziness.

• Fatigue.

• Skin rash or itching.

• Increased liver enzymes.

Precautions & Warnings

• Avoid use in allergy to PPIs.

• Long-term use may lead to vitamin B12 deficiency.

• May increase risk of bone fractures in prolonged high doses.

• Inform your doctor if you have liver problems.

• Avoid taking with rilpivirine (HIV medication).

• Elderly patients may require dose adjustments.

• Monitor magnesium levels if at risk of deficiency.

Drug Interactions

• Clopidogrel: may reduce effectiveness.

• Ketoconazole, Erlotinib: decreased absorption.

• Diazepam, Warfarin: increased blood levels.

• CYP2C19/CYP3A4 inhibitors or inducers may affect metabolism.

• Digoxin: slightly increased levels.

• Drugs affected by gastric pH (e.g., Amphetamine derivatives) may have altered absorption.

Food Interactions

• Avoid grapefruit and grapefruit juice.

• Limit or avoid alcohol.

• High-fat meals may delay absorption.

• Avoid excessive caffeine.

• Avoid spicy and acidic foods.

• Follow dietary adjustments if magnesium is low.

Storage/Disposal

• Store in a cool, dry place at room temperature.

• Keep away from sunlight and moisture.

• Do not dispose in household waste; follow proper disposal guidelines.

• Keep out of reach of children.

Laboratory Screening

• Ultrasound: for stomach health.

• H. Pylori Test: for stomach ulcer.

• Vitamin B12 Test: if using long-term.

Quick Tips

• Take as directed, do not change dosage.

• Swallow whole, take before meals.

• Complete full course of therapy.

• Store in a cool, dry place.

• Seek medical attention if symptoms persist.

Doctor’s Review — Dr. Imran Siddiqui, Consultant Gastroenterologist

“Esomeprazole 40mg is highly effective in managing acid-related disorders including GERD, ulcers, and Zollinger-Ellison syndrome. The capsule form provides controlled acid suppression, but monitoring is needed in elderly patients and those with liver or kidney impairment. Follow dosage instructions carefully to ensure efficacy and minimize side effects.”

Disclaimer

This product profile is for informational purposes only and does not replace professional medical advice. Always consult your doctor before using Esomeprazole 40mg Capsule, especially if you have existing health conditions or are on other medications.