Revalp Syrup contains 250 mg of divalproex sodium per 5 ml, an anti-epileptic drug that helps control seizures by stabilizing electrical activity in the brain. It works by increasing levels of GABA, a calming neurotransmitter, which reduces the likelihood of seizures in epilepsy. Beyond seizure control, it’s also used to prevent migraines by calming overactive neural signals. The syrup form makes it easier to dose, especially for those who struggle with tablets, and is typically taken under close medical supervision due to its potency.
Expert Review
Dr. Shahid Mukhtar, a distinguished Pakistani neurologist and epilepsy specialist at Shifa International Hospital, Islamabad, explains that divalproex sodium is effective for managing various epilepsy types by enhancing GABA activity. He notes its role in reducing seizure frequency and migraine occurrence but stresses the importance of monitoring liver function and blood counts, as it can affect these systems, particularly in long-term use.
Primary Uses
- Controls seizures in all forms of epilepsy.
- Prevents migraine headaches.
Indications
Used to treat epilepsy (all seizure types) and prevent migraines in patients unable to take oral valproate temporarily (via injection).
Side Effects
Some may experience stomach upset, weight gain, hair loss, headaches, liver issues, rashes, aggression, or bone marrow problems. Contact your doctor if these persist or worsen.
Warnings
- Pregnancy: Use only if no safer options exist, as it may harm the fetus. Consult your doctor.
- Lactation: Not recommended for breastfeeding mothers.
- Driving: Avoid driving, as it may cause drowsiness or impaired focus.
- Alcohol: Skip alcohol to prevent worsening side effects like liver strain.
Precautions
- Monitor liver function and blood counts regularly, especially with long-term use.
- Use cautiously if you have kidney issues or a history of diabetes (may cause false-positive urine tests).
- Women of childbearing age should discuss contraception, as it may pose risks to pregnancy.
Contraindications
Avoid if you have:
- Active or past liver disease.
- Pancreatitis (pancreas inflammation).
- Sun sensitivity or known allergy to divalproex sodium.
How to Use
Take orally as prescribed, typically with food to reduce stomach upset. The dose depends on age, weight, and condition severity—often starting low, especially for older adults. If using the injectable form, a healthcare professional will administer it. Follow your doctor’s instructions closely.
Storage
Store at room temperature (18-25°C), away from light, moisture, and children. Keep the bottle tightly sealed and check the expiration date before use.
Quick Tips
- Take with food to minimize stomach discomfort.
- Stick to a consistent schedule for steady blood levels.
- Don’t stop suddenly—consult your doctor to taper off.
- Report unusual symptoms like yellowing skin or severe fatigue immediately.
Disclaimer
This information is for general guidance only. Consult a doctor for personalized advice on side effects, precautions, or interactions, as individual needs vary.

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