Solu-Cortef

Solu-Cortef Injection 100 mg

General Description

Solu-Cortef Injection contains Hydrocortisone Sodium Succinate, a water-soluble corticosteroid with potent anti-inflammatory and immunosuppressive properties. It is pharmacologically equivalent to natural hydrocortisone, allowing for rapid systemic activity when immediate corticosteroid response is clinically required. The formulation is particularly effective in acute conditions where quick restoration of cortisol action is necessary — such as in shock, trauma, allergic reactions, or post-operative stress.

Pharmacological Classification

• Generic Name: Hydrocortisone Sodium Succinate

• Brand Name: Solu-Cortef Injection

• Drug Class: Corticosteroid / Glucocorticoid

• Therapeutic Category: Anti-inflammatory / Immunomodulating Agent

• Dosage Form: Injection (Vial)

• Prescription Status: Yes

Composition

Each vial contains:

• Hydrocortisone Sodium Succinate equivalent to Hydrocortisone 100 mg
  Inactive components may include sodium phosphate buffers to maintain pH stability.

Mechanism of Action

Hydrocortisone Sodium Succinate acts as a synthetic analog of endogenous cortisol, exerting:

• Anti-inflammatory effects: Inhibits the release of inflammatory mediators such as prostaglandins and cytokines.

• Immunosuppressive action: Reduces immune cell activity and limits excessive immune response.

• Metabolic regulation: Influences carbohydrate, protein, and lipid metabolism, helping the body respond to physical stress.

Because of its high water solubility, the succinate form enables rapid intravenous absorption and fast onset of action, typically within one hour after administration.

Pharmacokinetics

• Onset of Action: Within 1 hour of IV administration

• Duration: Variable (4 to 12 hours depending on dose and patient status)

• Metabolism: Primarily in the liver

• Excretion: Renal (urine)

• Half-life: 1.5 to 2 hours (plasma)

Clinical Function

Hydrocortisone Sodium Succinate is utilized in hospital and emergency settings for acute inflammatory and allergic conditions.
Its pharmacological profile allows rapid restoration of glucocorticoid activity in critical states such as:

• Post-operative or traumatic shock

• Severe allergic and anaphylactic reactions

• Acute adrenal insufficiency

• Exacerbations of inflammatory disorders

• Severe respiratory distress or autoimmune flares

These therapeutic effects are achieved through short-term, controlled administration by qualified healthcare professionals.

Dosage

Contains Hydrocortisone Sodium Succinate 100 mg per vial.
Dosage varies based on clinical condition and patient response; administration is strictly under medical supervision via intravenous or intramuscular routes.

Side Effects

Commonly Observed Effects:

• Transient burning or stinging at injection site

• Mood changes or irritability

• Increased appetite or weight fluctuation

• Elevated blood pressure or glucose levels

Serious Adverse Effects (Reported in Prolonged or High Dose Therapy):

• Allergic reactions (rash, swelling of face, difficulty breathing)

• Peptic ulcers or gastrointestinal bleeding

• Thrombosis or embolism (blood clot formation)

• Raised intracranial pressure (pseudotumor cerebri in children)

• Adrenal suppression with long-term use

Any unusual or persistent reaction requires medical review.

Drug Interactions

Hydrocortisone Sodium Succinate may interact with several agents, including:

• Anticoagulants (Warfarin) – altered bleeding tendency

• NSAIDs and Aspirin – increased risk of gastric ulceration

• Antidiabetics – possible hyperglycemia

• Anticonvulsants (Phenytoin, Carbamazepine) – enhanced metabolism of steroids

• Immunosuppressants (Ciclosporin, Tacrolimus) – additive effects

• Vaccines – reduced vaccine efficacy

• Grapefruit juice – may alter plasma levels

Drug interaction review is essential prior to administration.

Contraindications

Use of Hydrocortisone Sodium Succinate is contraindicated in patients with:

• Known hypersensitivity to hydrocortisone or corticosteroid preparations

• Untreated systemic fungal infection

• Recent or planned live vaccination

• Severe allergic reaction to any formulation component

Precautions

• Long-term use may suppress natural cortisol production.

• Regular monitoring of electrolytes, blood glucose, and blood pressure is advised in clinical practice.

• Use with caution in patients with osteoporosis, diabetes, hypertension, or psychiatric conditions.

• Visual disturbances due to central serous chorioretinopathy have been reported.

Warnings

1. Neonatal Use: Premature infants receiving hydrocortisone may require monitoring of heart function and structure.

2. Infection Risk: Corticosteroids can mask signs of infection; prompt medical evaluation is essential if infection is suspected.

3. Epidural Lipomatosis: Prolonged high-dose therapy can lead to abnormal fat deposition around the spine.

Storage Conditions

• Store at room temperature (15–25 °C).

• Keep away from direct light and heat.

• Protect from moisture and freeze damage.

• Keep out of reach of children.

Additional Information

• Pregnancy Category: Consult a physician before use.

• Control Drug: No

• Availability: Vial containing 100 mg Hydrocortisone Sodium Succinate for reconstitution and parenteral use.

Quick Reference

Medical Disclaimer

The above information is provided for educational and informational purposes only.
It does not constitute medical advice, diagnosis, or a prescription.
For individual medical guidance, dosage determination, or emergency management, please consult a licensed doctor or healthcare professional in Pakistan.